预后营养指数和肺炎死亡率:中国的一项回顾性队列研究
Zhengrong Ding1,2,3, Yunxue He1,2,3, Xue Guo1,2,3
1The Tenth Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Frontiers in nutrition
|October 31, 2025
概括
较低的预后营养指数 (PNI) 评分与中国肺炎患者的死亡风险增加有关. 这项研究强调PNI是肺炎患者结果的关键指标.
科学领域:
- 临床医学 临床医学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 肺炎是一个重大的全球健康挑战,营养状况影响患者的治疗结果.
- 预后营养指数 (PNI) 是一种随时可用的生物标志物,反映了营养状况和免疫功能.
研究的目的:
- 调查诊断性营养指数 (PNI) 与中国肺炎患者的死亡风险之间的关联.
- 在这个患者队列中探索PNI水平和短期死亡结果之间的关系.
主要方法:
- 一项回顾性队列研究,涉及635名来自中国六家医院 (2013-2019) 的成年肺炎患者.
- 考克斯回归分析,限制立方线 (RCS) 模型和卡普兰-梅尔生存分析被用来评估PNI和死亡率.
- 死亡率在不同PNI领域进行了比较.
主要成果:
- 每增加1个单位的PNI与30天 (HR=0.950) 和90天 (HR=0.955) 死亡风险的显著降低有关.
- 在最高PNI三位数的患者,与最低三位数相比,30天 (HR=0.335) 和90天 (HR=0.394) 的死亡风险明显较低.
- RCS和Kaplan-Meier分析证实了PNI和死亡风险之间的反向关系.
结论:
- 较差的预后营养指数 (PNI) 评分与中国肺炎患者的死亡率增加有显著关联.
- PNI作为肺炎死亡率的有价值的预测生物标志物,表明营养干预的潜力.
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