报道了kratom和发作之间的联系:一个系统的审查
Toby Turla1, Grayson Abele1, My Hua2
1Paustenbach and Associates, Denver, CO, United States.
Frontiers in pharmacology
|October 31, 2025
概括
这项研究发现,没有足够的证据将kratom使用与发作联系起来. 有限的毒理学数据和不完整的医疗记录阻碍了对这种草药补充剂建立因果关系.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 毒理学 毒理学 毒理学
背景情况:
- 克拉 (Mitragyna speciosa) 是一种草药补充剂,因其 analgesic 和 euforic 作用而受欢迎.
- 美国食品和药物管理局 (FDA) 发布了关于kratom潜在副作用的警告,包括发作.
- 发作经常报告与 kratom 消费相关的不良事件.
研究的目的:
- 为了调查 kratom 消费和发作发生之间的潜在因果关系.
- 评估现有的科学文献和不良事件数据库,寻找将kratom与发作联系在一起的证据.
主要方法:
- 进行了系统的文献搜索,寻找有关 kratom 使用和发作的同行评审文章.
- 分析了来自FDA的CAERS和FAERS数据库的不良事件数据.
- 在审查中包括案例报告,案例系列和观察性研究.
主要成果:
- 十一篇文章符合纳入标准,详细介绍了20名经历后发作的患者.
- 只有一个患者在他们的系统中有量化证据证明mitragynine (kratom的活性化合物).
- 不良事件数据库显示,4.5%的FAERS和较低比例的CAERS与kratom相关的报告中出现了发作,关于kratom数量或已确认使用的数据有限.
结论:
- 目前的证据不足以确定kratom和发作之间的因果关系.
- 有限的定量毒理学数据,不完整的医疗记录,以及一般人群中发作的流行率有助于得出这一结论.
- 需要进一步研究强有力的毒理学数据,以澄清 kratom 的神经效应.
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