生活空间流动性对社区居住的老年中风患者营养状况和认知功能之间的关系的纵向调解效应
Yixian Lei1,2, Haixin Bai3, Hongna Kang3
1Harbin Medical University, Daqing Campus, Daqing, Heilongjiang, China.
Frontiers in public health
|October 31, 2025
概括
老年中风患者的营养不良可以通过减少生活空间移动性 (LSM) 恶化认知功能. 早期的营养支持和LSM改善对于中风幸存者的更好的长期认知结果至关重要.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 营养科学 营养科学
背景情况:
- 脑卒中后的认知障碍是老年人面临的重大挑战.
- 营养状况和生活空间流动性 (LSM) 是影响恢复的公认因素.
- 在中风幸存者中营养,LSM和认知之间的相互作用需要进一步的纵向研究.
研究的目的:
- 探索社区居住的老年中风患者营养状况,LSM和认知功能之间的因果关系.
- 调查LSM在营养状况和中风后认知功能之间的关联中的纵向调解作用.
主要方法:
- 招募了284名缺血性中风患者 (≥60岁),随访时间为3,6个月和9个月.
- 评估营养状况 (MNA-SF),LSM (LSA-C) 和认知功能 (MMSE).
- 使用线性混合效应模型 (LMM) 和交叉滞后面板模型 (CLPM) 进行纵向分析.
主要成果:
- LMM显示营养状况显著影响认知功能,LSM部分介导这种效果 (24.94%的总效果).
- CLPM表明,LSM对T2-T3通路的完全调解,具有显著的间接效应和非显著的直接效应.
- 这两种分析方法都为LSM的调解作用提供了补充证据.
结论:
- 营养不良间接导致老年中风患者的认知障碍,因为它在慢性康复期间限制了LSM.
- 对营养不良的早期发现和干预至关重要.
- 改善LSM的策略对于提高中风后护理中的长期认知功能至关重要.
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