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在肠道穿孔中死亡的术前预测因素
Fırat Canlıkarakaya1, Serhat Ocaklı2, İbrahim Doğan3
1Amasya University, Faculty of Medicine, Department of General Surgery, Amasya, Türkiye.
Biomolecules & biomedicine
|October 31, 2025
概括
专/肌素比率,患者年龄和血清专素水平有效预测肠道穿孔病例的死亡率. 患有COVID-19的病史会增加因缺血导致穿孔的风险.
科学领域:
- 一般外科病理学 整体外科病理学
- 临床生物化学 临床生物化学
背景情况:
- 肠道穿孔是一种常见的,危及生命的手术紧急情况.
- 确定死亡率预测因素对于患者管理至关重要.
研究的目的:
- 评估临床和生化参数,以预测肠道穿孔死亡率.
- 评估COVID-19病史对穿孔病因和结果的影响.
主要方法:
- 对144名接受肠道穿孔手术的患者 (2019-2024) 的回顾性分析.
- 评估白蛋白/肌素比率,年龄,血清白蛋白,CRP,以及COVID-19病史.
- 使用后勤回归和接收器运行特征 (ROC) 分析进行统计分析.
主要成果:
- 总的死亡率为25%.
- 死亡率的独立预测因素:白蛋白/肌素比率<3.38 (OR: 12.666),年龄>66岁 (OR: 3.273),血清白蛋白<3g/dL (OR: 5.653).
- 专/肌素比率显示出最高的预测准确度 (AUC:0.879).
- 在非COVID-19患者中,COVID-19病史与较高的缺血相关穿孔 (87.5%) 与恶性病 (41.4%) 相关 (p<0.001).
结论:
- 专/肌素比率,年龄和血清专素水平是肠道穿孔病例中死亡率的强有力的预测因素.
- COVID-19 病史显著提高了缺血性肠道穿孔的风险.
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