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Updated: Jan 12, 2026

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
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基于LC-MS/MS的研究,对CYP3A4基质恩扎胺和雷帕格林胺在老鼠中的药理相互作用进行了研究

Gangireddy Navitha Reddy1, Mani Surya Kumar Palepu2, Rajesh Sonti1

  • 1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Hyderabad (NIPER-H), Balanagar, Telangana, 500037, India. rajesh.sonti@niperhyd.ac.in.

Analytical methods : advancing methods and applications
|October 31, 2025
PubMed
概括

用于前列腺癌的恩扎胺可以改变repaglinide在2型糖尿病患者中的作用. 这种由CYP3A4诱导驱动的药物动力学相互作用需要在两种药物一起处方时进行临床考虑.

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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