胎盘缺陷和晚期发作的胎儿生长限制适合妊娠年龄的胎儿
Ceska gynekologie
|October 31, 2025
概括
晚期发病的胎儿生长限制,通常是由于胎盘缺陷,会带来诊断挑战. 早期发现亚临床病例对于改善围产期结果至关重要.
科学领域:
- 周围生理学 周围生理学
- 产科 产科 产科 产科 产科
- 胎儿医学 胎儿医学
背景情况:
- 胎儿生长限制 (FGR) 阻碍胎儿发育,主要是由于胎盘功能障碍.
- 晚期发病的FGR (32周后) 由于微妙的迹象,难以诊断.
- 亚临床胎盘缺陷可能会影响适合孕期体重的胎儿.
研究的目的:
- 为了突出晚发性FGR的诊断挑战.
- 强调需要改善亚临床胎盘缺陷的检测.
- 强调诊断缺陷对识别高风险怀孕的影响.
主要方法:
- 对晚发性FGR的临床和超声波表现的审查.
- 分析与晚期胎盘功能障碍相关的特征 (多普勒模式,生长轨迹,生物标志物,胎盘组织学).
- 讨论目前的诊断局限性,在没有明显的FGR的情况下识别胎盘缺陷.
主要成果:
- 晚期发病的FGR呈现出微妙的临床和超声波发现.
- 胎盘功能障碍指标包括多普勒异常,生长减缓,生物标志物变化和特定的胎盘组织学.
- 现有的诊断工具很难及时发现胎盘缺陷,特别是在没有明显的FGR的情况下.
结论:
- 对于识别胎盘缺陷存在重大诊断差距,特别是在亚临床病例中.
- 及时诊断是有限的,这阻碍了对有不良结果风险的胎儿的识别.
- 对于可靠的胎盘缺陷产前检测,需要进一步的进展.
相关概念视频
Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Fetal Circulation
2.5K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.5K
Nature and Nurture
22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K


