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针对2型糖尿病内皮功能障碍的生物标志物和疗法:向前迈出了一步
Ying Jie Chee1,2, Wann Jia Loh3,4,5, Rinkoo Dalan1,2
1Department of Endocrinology, Tan Tock Seng Hospital.
Current opinion in endocrinology, diabetes, and obesity
|October 31, 2025
概括
在2型糖尿病 (T2DM) 中早期发现内皮功能障碍是预防动脉样硬化心血管疾病 (ASCVD) 的关键. 新的血液和成像测试显示,有望识别高风险个人进行初级预防.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是2型糖尿病 (T2DM) 患者的主要死亡原因.
- 内皮功能障碍是动脉样硬化的前体,随着时间的推移,它会默默地发展.
- 针对早期内皮功能障碍的初级预防策略对于减轻ASCVD风险至关重要.
研究的目的:
- 审查评估内皮功能的新兴方法.
- 突出内皮功能障碍在T2DM中ASCVD发展中的作用.
- 强调早期识别和干预的重要性.
主要方法:
- 对内皮功能新兴的基于血液的生物标志物的审查 (例如,细胞外囊泡,再生标志物,多基因风险评分).
- 评估生理成像技术,特别是臂动脉的流媒扩张 (FMD).
- 对影响内皮功能的非药理和药理干预措施的证据分析.
主要成果:
- 新的血液检测和标准化的口炎为评估内皮功能提供了有希望的途径.
- 内皮功能生物标志物和口炎越来越多地被用作治疗反应的替代标志物.
- 证据支持各种策略在改善内皮质健康方面的有效性.
结论:
- 基于血液和成像的内皮功能评估在早期预防策略中取得了重大进展.
- 需要对多种不同人群进行进一步的研究,以验证这些用于识别高风险个体的方法.
- 增强的内皮功能评估可以指导T2DM患有ASCVD风险的患者的密集初级预防工作.
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