高功能学龄前男孩患有自闭症谱系障碍的功能性连接性改变
Qin Zhao1,2, Yan Luo3, Xinjie Mei3
1Clinical Research Center for Children with Autism of Chongqing, The Beibei Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Applied neuropsychology. Child
|October 31, 2025
概括
患有自闭症谱系障碍 (ASD) 的学龄前男孩表现出弱化的远程大脑连接,特别是在三角洲频段. 这种功能连接的改变与ASD症状的严重程度有关,为早期诊断提供了潜在的可能性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物标志物 生物标志物
背景情况:
- 信息处理缺陷是自闭症谱系障碍 (ASD) 症状的核心.
- 功能连接对于大脑信息整合至关重要.
- 之前的研究发现,ASD的老年人具有非典型的连接性,但学前年龄的变化仍未得到充分研究.
研究的目的:
- 调查与典型发育 (TD) 同龄人相比,患有自闭症的学龄前男孩的静止状态脑电图 (EEG) 功能连接.
- 探索功能连接和ASD症状严重程度之间的关系.
主要方法:
- 休息状态EEG数据从具有高功能学龄前男孩与ASD和TD对照组中收集.
- 基于网络的统计 (NBS) 用于识别功能连接的差异.
- 儿童自闭症评分表 (CARS) 测量了ASD症状的严重程度.
- 相关性分析检查了连接性和症状之间的联系.
主要成果:
- 在ASD学龄前男孩中观察到,三角波段 (1-4 Hz) 的长距离功能连接下降.
- 这些变化包括半球内和半球间的连接.
- 连接性差异显示了很大的效果大小和与特定的ASD症状严重程度指标的显著相关性.
结论:
- 患有自闭症的学龄前男孩表现出一个弱化远程功能连接的模式.
- 这种失联与ASD核心症状有关,这表明它在疾病的表现中发挥了作用.
- 这些发现支持功能连接作为ASD查和干预计划的早期生物标志物的潜力.
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