相关实验视频

Updated: Jan 12, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

扩大骨关节炎疼痛缓解与neosaxitoxin使用酸盐核心聚合物微粒

Hengli Zhang¹, Helna M Baby¹, Shingo Ishihara²

¹Department of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@neu.edu.

|October 31, 2025

概括

新的研究探讨了通过先进的微粒物传递的neosaxitoxin (NSTX) 来缓解骨关节炎 (OA) 的持续疼痛. 这种新的方法为慢性OA疼痛管理提供了长时间的止痛效果.

科学领域:

生物医学工程生物医学工程
疼痛管理疼痛管理
药理学药理学是指药理学的学科.

背景情况:

骨关节炎 (OA) 是慢性疼痛的主要原因,目前的治疗方法提供有限的缓解和潜在风险.
电压通道 (Na_V1.7) 是OA疼痛的关键标,但短效阻断剂如neosaxitoxin (NSTX) 具有有限的效用.
开发持续释放系统对于有效的,长期的OA疼痛管理至关重要.

研究的目的:

评估NSTX的关节内 (IA) 输送,以缓解OA的疼痛.
开发和评估一种用于持续释放NSTX的新型酸盐-多酸 (乳酸-co-甘油酸) 微粒 (AlgPLGA-MP) 平台.
通过使用表面功能来增强输送系统的联合停留时间.

主要方法:

开发了AlgPLGA-MPs与酸盐核心,以改善NSTX封装和控制释放.
在小鼠OA模型中测试了NSTX载入AlgPLGA-MPs的IA注射,以减轻疼痛和持续时间.
功能化微粒表面与阿维丁 (AvAlgPLGA-MP) 促进静电结合和延长关节内保留.

主要成果:

在OA小鼠模型中,关节内NSTX提供了短期的疼痛缓解.
在OA模型中,AlgPLGA-MPs显著延长至1周的疼痛缓解.
艾维丁功能化微粒显示长时间的关节内保留和生物相容性.

结论:

尼奥沙西托克辛 (NSTX) 是一种强大的止痛药,用于慢性OA疼痛,当通过持续释放系统输送时.
酸盐核心PLGA微粒代表了一个安全有效的平台,用于持续输送像NSTX这样的亲水性止痛药.
这种交付策略具有重要的翻译潜力,用于管理慢性疼痛疾病.

更多相关视频

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Published on: June 7, 2024

相关概念视频

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...