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Updated: Jan 12, 2026

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连接omeDB2025:一个严格策划的,多种实验支持的连接体-受体相互作用的多种资源

Peiwen Liu¹, Sakura Eri B Maezono², Weitao Lin¹

¹Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.

Nucleic acids research

|October 31, 2025

概括

更新的connectomeDB2025数据库提供了基于的配体受体相互作用的严格策划的目录,增强了单细胞和空间转录学中的细胞-细胞通信分析.

科学领域:

计算生物学是一种计算生物学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

细胞-细胞通信网络推断对于分析单细胞RNA-seq和空间转录组学数据至关重要.
准确的分析依赖于全面的,经过实验验证的体受体相互作用数据库.

研究的目的:

为了介绍connectomeDB2025,一个更新的,开放访问的数据库,实验支持的基于的配体-受体相互作用.
通过整理和扩展现有的相互作用数据来提高细胞-细胞通信分析的准确性和稳定性.

主要方法:

从现有的数据库中进行批判性审查和删除不支持的交互 (connectomeDB2020,CellChatDB,CellPhoneDB等). ) 的情况.
通过人工智能辅助的文献挖掘和手动策划来识别和添加新的,经过实验验证的联体受体对.
将每个相互作用与研究文章中的初级实验证据联系起来.

主要成果:

连接组DB2025包含3579个脊椎动物相互作用,新增827个新对和718个新的支持文章.
删除了超过2900个不支持的交互,2359个证据链接是独家的connectomeDB2025.
该数据库提供了5429个证据链接,确保每次相互作用至少有一个初级实验验证.

结论:

连接omeDB2025是目前可用的最强大的配体受体数据库,具有主要的实验证据.
该数据库可方便在多种脊椎动物物种中进行准确的细胞-细胞通信分析.
在线资源为研究人员提供可搜索和下载的数据.

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