多囊卵巢形态和慢性致病率和死亡率在PCOS
Nir Kugelman1,2, David V Morris3, Marie-Pier Bastrash4,5
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
JAMA network open
|October 31, 2025
概括
患有多囊性卵巢综合征 (PCOS) 的女性的多囊性卵巢形态 (PCOM) 与较早的代谢问题和更高的2型糖尿病风险有关. 然而,PCOM在这个长期研究中没有显示出死亡率或其他慢性疾病的风险增加.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 纵向研究 纵向研究
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,与胰岛素抵抗和心血管风险有关.
- 不同的PCOS卵巢形态亚型的长期健康影响尚不清楚.
研究的目的:
- 调查长期发病率和死亡率是否在患有多囊性卵巢形态 (PCOM) 和没有多囊性卵巢形态 (PCOS) 的女性之间有所不同.
- 在37年的随访期间评估PCOM与各种慢性健康状况和死亡率的关联.
主要方法:
- 一项前性队列研究跟踪了340名患有PCOS的女性,长达37年.
- 卵巢形态通过超声波评估,通过特定的毛囊数量和分布来定义PCOM.
- 包括全因死亡率和慢性疾病在内的结果使用统计分析进行了评估,并根据混因素进行了调整.
主要成果:
- 患有PCOM的女性在入学时更年轻,体质量指数,胆固醇比率,LH,雄激素,禁食胰岛素和甘油三素都更高.
- 群体之间的死亡率相似,尽管患有PCOM的女性往往在较年轻时死亡.
- 患有PCOM的女性中非胰岛素依赖性糖尿病的发生率明显高 (23.8%对9.3%),这一发现得到了多变量分析的证实.
结论:
- 在PCOS中PCOM表型与较早的代谢异常和2型糖尿病风险增加有关.
- 在这个队列中,没有发现PCOM与总死亡率或其他慢性疾病的增加有关.
- 这些发现强调了监测PCOS妇女的代谢健康的重要性,特别是那些患有PCOM的妇女.
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