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kongenital diaphragmatic hernia - 有没有一个性别特定的严重程度的表型?
Angelo Zarfati1,2, Luca Pio3,4, Arimatias Raitio5
1Department of Pediatric Surgery, Université Paris-Saclay, Assistance Publique - Hôpitaux de Paris (AP-HP), Bicêtre Hospital, Paris, France.
European journal of pediatrics
|October 31, 2025
概括
先天性隔膜 (CDH) 结果显示,女性的死亡率上升的趋势,女性也有更多的心脏和染色体异常. 在一项研究中,男性患肺高血压更多,这表明CDH中潜在的性别特异性风险.
科学领域:
- 儿科手术 儿科手术
- 新生儿医学 新生儿医学
- 医学遗传学 医学遗传学
背景情况:
- kongenital diaphragmatic hernia (CDH) 是一种严重的疾病,死亡率很高,通常是由于肺部缺血和肺高血压.
- 现有研究尚未充分探索CDH结果和相关疾病的潜在基于性别的差异.
研究的目的:
- 调查先天性隔膜 (CDH) 患者产前和产后结果的性别特异性差异.
主要方法:
- 根据PRISMA指南进行了系统审查和元分析.
- 来自多个数据库 (Cochrane,PubMed,Embase,Web of Science,Medline) 的数据进行了合成.
- 分析了16项涉及14109名患者 (0-18岁) 的研究,以比较男性和女性CDH结果.
主要成果:
- 与男性 (24%) 相比,女性 (28%) 观察到较高死亡率的非显著趋势.
- 与男性相比,女性心脏异常 (22.9%) 和染色体疾病 (9%) 的发生率明显高.
- 在一项研究中,肺高血压在男性 (70%) 比女性 (60%) 更频繁;缺陷横向性和临床参数显示性别差异很小.
结论:
- 女性CDH患者的死亡率增加和心脏和染色体异常的发病率增加趋势,表明潜在的"高风险"表型.
- 在一项研究中,男性有更多的肺高血压,突出了CDH呈现的性别特异性变化.
- 进一步的研究对于阐明这些性别特异性差异及其对先天性隔膜间管理的临床影响至关重要.
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