在SARS-CoV-2之后,儿童和青少年的持续神经病后症:一个范围审查
Salma Zouari Mallouli1,2, Daniel Munblit3,4, Ekaterina Iakovleva4
1Child Neurology Department at Hedi Chaker, Sfax University Hospital, Sfax, Tunisia. mallouli.salma26@gmail.com.
Infection
|October 31, 2025
概括
持续的神经症状,包括疼痛和睡眠问题,是COVID-19感染后儿童和青少年的一个重大问题. 本次审查强调了长期COVID-19在这个年龄组中的实质性负担.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
背景情况:
- 由于COVID-19的流行,导致了重要的健康规划和研究重点.
- 急性疾病的长期后果,制措施和持续的症状构成了全球性的挑战.
- 了解对儿童和青少年的影响对于量身定制的健康指令至关重要.
研究的目的:
- 审查在SARS-CoV-2感染后儿童和青少年中持续的神经病变的频谱.
- 为未来关于儿科长期COVID-19的健康政策提供信息.
- 综合全球关于年轻人群的神经表现的数据.
主要方法:
- 根据PRISMA-ScR指南进行的范围审查.
- 在主要数据库 (PubMed,谷歌学者,科学网,Cochrane,WHO COVID) 进行文献搜索.
- 包括关于2020年9月至2024年9月儿科长期COVID-19神经症状的同行评审文章.
主要成果:
- 疼痛和感官问题是最常见的神经系统后果 (81.5%).
- 还报告了睡眠障碍 (15.9%) 和认知困难 (2.4%).
- 神经症状在11-16岁的年龄组中更常见,免疫能力较强的儿童的风险更高.
结论:
- 在COVID-19之后,儿童和青少年存在相当大的持续神经症状负担.
- 这些发现需要在儿童群体的医疗保健决策中加以考虑.
- 对于儿科长期COVID-19的进一步研究和有针对性的干预措施是有必要的.
相关概念视频
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...


