基础交感神经系统在自闭症中的功能:神经化学研究的系统性审查
Krisha Neupane1, Saketh Pillalamarri1, George M Anderson2
1Georgia Institute of Technology Dual Enrollment Program, 219 Uncle Heinie Way, Atlanta, GA, USA.
Journal of autism and developmental disorders
|October 31, 2025
概括
自闭症 (ASD) 不显示基底交感神经系统 (SNS) 功能增加. 然而,血上升的上腺素和上腺素表明ASD患者对急性压力的生理反应加剧.
科学领域:
- 神经科学是一个神经科学.
- 自闭症谱系障碍研究研究
- 生理学 生理学 生理学
背景情况:
- 交感神经系统 (SNS) 功能是理解自闭症谱系障碍 (ASD) 病因和临床的关键领域.
- 现有的研究提出了相互矛盾的观点,关于ASD患者是否经历慢性过度兴奋或对压力的反应加剧.
研究的目的:
- 系统地审查神经化学研究,调查神经系统在ASD中的功能.
- 为了澄清ASD是否以慢性过度兴奋,增加的应激反应或两者的特征.
主要方法:
- 在PubMed,Scopus,奥维德和科学网上进行了系统的文献搜索.
- 搜索术语包括北上腺素 (NE),上腺素 (EPI),它们的代谢物,以及有关ASD的诊断术语.
- 研究被三个独立审查员选.
主要成果:
- 在ASD和对照组之间没有发现尿液测量或血代谢物测量的显著差异.
- 血上腺素 (EPI) 在ASD组显著升高,血上腺素 (NE) 呈现增加趋势.
- 在各组之间,同情度的差异是相似的,在ASD中观察到典型的夜间减少.
结论:
- 在患有自闭症的个体中,基底神经系统功能没有升高.
- 血EPI和NE升高表明在ASD中对急性压力因素的反应性增加.
- 在ASD中增加的压力反应可能源于交感系统的刺激增加,而不是慢性过度兴奋.
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