2009年至2021年伊朗的抗糖尿病药物使用模式,负担能力和成本分析:需要修订指南
Saman Zartab1,2, Hadi Abbasian3
1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
PloS one
|October 31, 2025
概括
糖尿病药物使用和支出显著增加. 虽然必需胰岛素仍然负担得起,但新的抗糖尿病药物越来越负担不起,需要对合理药物使用的政策审查.
科学领域:
- 药物经济学 药物经济学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病患病率在全球范围内不断上升,给医疗保健系统带来了巨大的经济负担.
- 很大一部分糖尿病患者正在与无法控制的疾病作斗争,这凸显了有效药物管理的必要性.
- 监测抗糖尿病药物使用率和可负担性对于明智制定健康政策至关重要.
研究的目的:
- 评估在一段时间内对抗糖尿病药物的使用模式和趋势.
- 评估抗糖尿病药物的可负担性,与最低每日工资相关.
- 将药物使用情况与世界卫生组织的必需药物清单进行比较.
主要方法:
- 追溯性描述性研究设计.
- 解剖治疗分类 (ATC) 和定义每日剂量 (DDD) 方法用于利用分析 (DID).
- 药物利用90% (DU-90) 方法和负担能力评估,通过将药物成本与最低工资进行比较.
主要成果:
- 抗糖尿病药物的使用量从22.5增加到63.9 DID (9.05%的复合年增长率),支出增加了18倍.
- 每个DDD的成本大幅增加;DU-90名单与世卫组织的基本药物保持一致.
- 人类胰岛素是负担得起的,但胰岛素类似物和新型非胰岛素药物 (如empagliflozin,sitagliptin) 在很大程度上无法负担得起.
结论:
- 抗糖尿病药物的使用和支出急剧增加,成本超过使用.
- 引入新型,负担不起的抗糖尿病药物是一个越来越令人担忧的问题.
- 建议对糖尿病管理指南进行修订,以促进合理的处方和提高药物负担能力.
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