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多发性骨髓瘤的种族差异:生物异质性,治疗机会和预后影响

Malaika J Mason¹, Brian C Chiu¹

¹Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA.

Leukemia & lymphoma

|October 31, 2025

概括

多发性骨髓瘤 (MM) 存活率的种族差异尚不清楚,尽管非洲裔美国人 (AA) 的发病率更高. 本综述探讨了导致这些MM结果差异的遗传,分子和非生物因素.

科学领域:

血液学血液学血液学
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

多发性骨髓瘤 (MM) 不成比例地影响非洲裔美国人 (AA),与欧洲裔美国人 (EA) 相比,发病率更高,发病时间更早.
关于AA和EA群体之间MM生存差异的现有研究提出了相互矛盾的结果,表明AA患者的生存率更差,类似甚至更好.
在MM的临床结果受到患者特异性因素 (年龄,疾病严重程度,细胞遗传学),治疗变量和社会经济决定因素 (如获得护理) 的复杂组合的影响.

研究的目的:

在多种不同的人群中审查多发性骨髓瘤 (MM) 的遗传和分子异质性.
探索MM结果中种族和民族差异的潜在决定因素.
考虑减轻MM健康差异的战略.

主要方法:

文献综述侧重于MM的遗传和分子特征.
分析导致MM患者结局种族和民族差异的因素.
综合有关MM健康差异的当前知识.

主要成果:

关于非洲裔美国人 (AA) 与欧洲裔美国人 (EA) 的MM患者的生存结果的不确定的发现.
鉴定影响MM差异的遗传,分子和非生物因素.
承认影响不同人群MM临床结果的复杂相互作用.

结论:

需要进一步的研究来澄清MM存活率种族差异的决定因素.
解决差异需要了解生物和社会经济因素.
最终的目标是制定有针对性的战略,以减少多发性骨髓瘤的健康不平等.

关键词:

多发性骨髓瘤是一种多发性骨髓瘤.细胞遗传学细胞遗传学遗传学遗传学遗传学是一个在健康方面存在差异.医疗保健中的差异.生存结果的结果.

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