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Updated: Jan 12, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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DNA拓酶II促进了N6-腺 mRNA甲基化

Clara Megías-Fernández1, Irene Delgado-Sainz1, Alberto León-Halcón1

  • 1Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain.

Cell reports
|October 31, 2025
PubMed
概括

DNA拓酶II (TOP2) 支持转录延长,并促进mRNA N6 - 氨酸甲基化 (m6A). TOP2中毒阻碍了延长,但被缺陷的m6A抵消,影响RNA周转和拼接.

关键词:
科普:分子生物学 分子生物学在DNA上存在多聚酶.DNA拓学是什么意思?在METTL3中,METTL3是METTL3的第一个类型.RNA代谢,RNA代谢的过程的RNA聚合酶II.RNA 稳定性 RNA 稳定性标志性转录组学 标志性转录组学基因表达的基因表达方式m6A 修改的修改转录延长 延长 转录延长

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