怀孕期间发作与不良妊娠结果之间的关联:系统性审查和元分析

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Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

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Oladipupo Olalere¹, Saba Tariq^1,2, Olanike Ajijola³

¹Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.

PLoS medicine

|October 31, 2025

概括

怀孕期间的发作增加了母亲和婴儿的风险,包括较高的剖腹产率,周产期抑郁症和低出生体重. 识别高风险怀孕对于最佳护理至关重要.

科学领域:

产科和妇科产科和妇科
神经学神经学
公共卫生公共卫生

背景情况:

怀孕期间的发作对母亲和胎儿的健康都有风险.
社会经济因素可能会影响孕妇发病率和控制.

研究的目的:

系统地审查和元分析妊娠中发作和不良妊娠结果之间的关联.
评估社会经济/个人因素与怀孕期间发作发生之间的联系.

主要方法:

对患有的孕妇进行的观察性研究进行了系统审查和元分析.
搜索了多个数据库 (MEDLINE,Embase,CINAHL,PsycINFO) 到2025年5月.
使用随机效应模型计算聚合几率比率 (OR) 和95%置信区间 (CI).

主要成果:

孕妇的发作增加了剖腹产的几率 (OR 1.62),产周抑郁 (OR 2.20),以及对于妊娠年龄 (SGA) 婴儿的小 (OR 1.32).
在有的妇女中,早产 (OR 1.66),低出生体重 (OR 1.47) 和SGA婴儿 (OR 1.44) 的几率更高.
低收入 (OR 1.57) 和焦点 (OR 1.84) 与发作风险增加有关.

结论:

怀孕期间的发作与母亲和胎儿不良后果的风险显著增加有关.
风险分层是必要的,以确定有的孕妇在发作的风险更高.
优化护理需要对这一群体进行积极的风险评估和管理策略.

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