通过SIRI调解的CUN-BAE指数和抑郁症之间的关联:一项大型横截面研究
Muxi Li1, Yazhi Qi2, Mengru Cao3
1First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, China.
PloS one
|October 31, 2025
概括
通过Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) 指数测量的较高的身体脂肪与抑郁症风险增加有关. 系统性炎症反应指数 (SIRI) 部分调解了这种关系,表明炎症起到了作用.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 抑郁症是全球普遍存在的情绪障碍,也是导致残疾的重要原因之一.
- 纳瓦拉大学诊所 - 身体肥胖率估计器 (CUN-BAE) 指数量化了身体脂肪含量.
- 系统性炎症反应指数 (SIRI) 表示的炎症在各种健康状况中越来越多地被认可.
研究的目的:
- 调查CUN-BAE指数与抑郁症之间的关联.
- 检查SIRI在CUN-BAE和抑郁症之间的关系中的调解作用.
主要方法:
- 来自NHANES (2005-2020) 的31592名美国成年人 (年龄≥20) 的数据分析.
- 用权重多变量后勤回归和限制立方线 (RCS) 模型来评估关系和非线性.
- 使用引导复制品进行的调解分析评估了SIRI的调解效果.
主要成果:
- 患有抑郁症的个人表现出更高的CUN-BAE和SIRI水平.
- 在CUN-BAE中增加1个单位与患抑郁症的几率增加2%相关 (OR=1.02,P<0.001).
- 在CUN-BAE和抑郁症之间发现了显著的非线性正相关性,以及SIRI和抑郁症之间的J形曲线. SIRI部分调解了CUN-BAE-抑郁症联系 (3%的效果).
结论:
- CUN-BAE指数可以作为评估抑郁风险的潜在指标.
- 监测身体脂肪和炎症水平可以帮助早期发现有抑郁症风险的人.
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