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Updated: Jan 12, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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通过ATF6α和通过E2F1通过葡萄糖对β细胞增殖的双输入调节

Huguet V Landa-Galvan1, Thalia A Castro1, Jahi J Noel1

  • 1Division of Endocrinology, Diabetes and Metabolism and the Joan and Sanford I. Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY.

Diabetes
|October 31, 2025
PubMed
概括

激活转录因子6 (ATF6α) 通过E2F1促进胰腺β细胞的增殖,但需要葡萄糖. 循环素依赖性激酶4/6 (CDK4/6) 通过酸化视网膜母细胞瘤蛋白来实现这一过程,该蛋白作为葡萄糖传感器.

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