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Updated: Jan 12, 2026

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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Published on: July 5, 2022

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释放细胞机械生物学的治疗潜力

Yohalie Kalukula1, Giuseppe Ciccone1,2, Danahe Mohammed1,3

  • 1SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons-UMONS, B-7000 Mons, Belgium.

Science advances
|October 31, 2025
PubMed
概括

机械生物学探讨了物理力量如何影响细胞行为和疾病. 这个领域正在推动医学中的新疗法,从癌症到神经退行性疾病.

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Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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