相关实验视频
Updated: Jul 14, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
Juan Manuel Duarte1, Marcelo Fabián Garro2, María Eugenia Basile3
1Médico Neurólogo. División Neuropsicofarmacología, Hospital de Clínicas "José de San Martín", Facultad de Medicina, Universidad de Buenos Aires. Instituto de Neurociencias, Hospital Alemán, Buenos Aires, Argentina.. duarte@fmed.uba.ar.
即使在治疗之前,癌症也会损害认知功能,导致加速衰老. 机制包括炎症,神经毒性和荷尔蒙失衡,影响叶功能和认知储备.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 认知科学 认知科学
背景情况:
- 在化疗前的癌症患者中观察到认知功能受损.
- 癌症通过减少储量来加速生物和认知衰老.
- 叶功能障碍是由系统性炎症,神经毒性和荷尔蒙轴调节障碍引起的.
研究的目的:
- 探索癌症患者认知功能障碍背后的多方面的机制.
- 审查认知变化的神经生理学和神经成像证据.
- 讨论瘤综合征和非药物治疗策略.
主要方法:
- 对神经生理学研究的审查 (与事件相关的潜力).
- 分析结构和功能神经成像数据.
- 检查系统性炎症,金氨酸通路,下丘脑-垂体-上腺轴,外体和黑激素通路.
主要成果:
- 系统性炎症通过 kynurenine 途径导致神经毒性.
- 通过外体介导的遗传/表观遗传变化会影响氧化应激蛋白.
- 神经心理变化是由事件相关的潜力和神经成像证明的.
- 由神经神经元抗体识别的瘤性综合征,呈现出明显的中枢神经系统功能障碍模式.
结论:
- 癌症中的认知功能障碍是多因素的,涉及炎症,神经毒性和荷尔蒙变化.
- 非药物干预措施,如体育活动,CBT和正念是关键的治疗方法.
- 预防性埃斯基塔洛普拉姆建议用于特定的头癌患者.
相关概念视频
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Psychoneuroimmunology: Diabetes and Cancer

