在全胰腺切除术后的胃肠道症状负担与岛屿自移植,一个前性的观察性队列研究
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Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
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William Hirsch1, Elissa M Downs2, Martin Freeman3
1Department of Medicine, University of Minnesota, Minneapolis, MN.
Pancreas
|October 31, 2025
概括
经过全胰腺切除与小岛自身移植 (TPIAT) 的患者经常出现严重的胃肠道症状,如疼痛,胀气,恶心和腹. 小肠细菌过度生长 (SIBO) 加剧了这些问题,对生活质量产生了负面影响.
科学领域:
- 胃肠病学 胃肠病学
- 外科手术的结果
- 患者报告的结果
背景情况:
- 全胰腺切除术与小岛自身移植 (TPIAT) 是一种治疗严重胰腺炎的方法.
- 胃肠道 (GI) 症状和小肠道细菌过度生长 (SIBO) 是TPIAT后常见的.
研究的目的:
- 描述TPIAT后患者报告的胃肠道健康和生活质量 (QoL) 结果.
主要方法:
- 接受TPIAT的成年患者被纳入.
- 经过验证的问卷评估了胃肠道症状 (NIH PROMIS胃肠道症状量表) 和质量 (RAND 36,NIH HQL 14).
主要成果:
- 82名患者在手术后平均8年完成了调查.
- 与普通人群相比,TPIAT患者报告更严重的腹痛,气体/胀气,恶心/吐和腹.
- 之前的SIBO诊断与疼痛,气体/胀气和恶心/吐的严重程度增加相关 (p<0.05).
- 恶心/吐和腹显著恶化了 QoL 的结果.
结论:
- 与一般人群相比,TPIAT患者的显著胃肠道症状的发生率更高.
- SIBO与症状严重程度的增加有关,影响了QoL.
- 恶心/吐和腹是影响QoL后TPIAT的关键因素.
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