女性捐赠者性别与男性接受者的肝移植存活率下降有关,这与捐赠者和接受者人体测量独立
Marcio Fernandes Chedid1,2, Lucas Prediger1, Gabriel Lazzarotto-DA-Silva1
1Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Liver Transplant Program - Porto Alegre (RS), Brazil.
概括
女性捐赠者性别显著增加了肝移植死亡率,特别是在男性接受者中. 感染是移植后第一年死亡的主要原因.
科学领域:
- 移植研究 移植研究
- 器官移植的结果.
- 移植的生存因素
背景情况:
- 关于捐赠者性别对肝移植 (LT) 结果的影响的数据有限.
- 了解供体变量对于改善移植后存活率至关重要.
研究的目的:
- 为了研究肝移植后死亡率的预后因素.
- 具体评估捐赠者的性别对患者生存的影响.
主要方法:
- 从2011年12月到2018年12月,对202名肝移植接受者的回顾性分析.
- 总体患者存活率是主要的结局指标.
- 考克斯回归分析确定了死亡率的预测因素.
主要成果:
- 女性捐赠者的性别是增加整体死亡率的唯一预测因素 (HR 1.918,p=0.013).
- 捐赠者-接受者的人类测量差异与死亡率没有相关性.
- 卡普兰-梅尔1,3,5年和7年的生存率分别为81.6%,73.1%,67.6%和63%.
结论:
- 女性捐赠者性别与更高的肝移植后死亡率有关.
- 这种效应在男性接受者中是明显的,不管体型是否匹配.
- 感染是第一年内女性捐赠肝脏的男性接受者死亡的主要原因.
相关概念视频
Kidney Transplant I: Introduction
321
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
321
Bone Marrow Sampling and Transplants
858
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
858
Tissue Transplantation
885
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
885
Kidney Transplant II: Surgical Procedure
297
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
297


