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生物活性玻璃牙膏在预防幼儿牙方面的有效性:一项随机对照试验

Ting Li¹, Haiying Guo¹, Chang Liu¹

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

International dental journal

|October 31, 2025

概括

一种无化物生物活性玻璃 (BAG) 牙膏在预防幼儿牙 (ECC) 方面显示出与化物牙膏类似的结果. 然而,这两种治疗方法在幼儿中有效性有限,观察到明显的病进展.

科学领域:

儿科牙科儿科牙科
牙预防预防牙
生物材料在口腔健康中的作用

背景情况:

幼儿 (ECC) 是一个主要的全球口腔健康问题.
化物处理是标准的,但生物活性玻璃 (BAG) 显示出作为替代品的希望.
正在探索新的无化物选择,以预防空.

研究的目的:

为了比较无化物BAG牙膏与化物牙膏在预防ECC方面的有效性.
为了评估27个月内在学龄前儿童中下的增加和发病率.
评估BAG牙膏在儿童群体中的安全性和有效性.

主要方法:

这是一项双盲多中心随机对照试验,涉及1063名年龄在3-4岁的儿童.
参与者使用了7.5%的BAG牙膏 (测试) 或800ppm化物牙膏 (控制).
主要结局包括27个月腐烂,缺失和填充牙 (dmft) 和表面 (dmfs) 评分的变化.

主要成果:

在27个月后,BAG和化物组之间没有发现脏增加或发病率的统计学上显著差异.
两组在12个月和27个月的时间表显示出可比的病进展.
没有报告任何不良事件,这表明这两种干预措施的耐受性很好.

结论:

在27个月的时间内,无化物BAG牙膏在预防ECC方面表现出与标准化物牙膏相似的有效性.
这两种干预措施都显示出相当大的虫病进展,这表明在这个学龄前人口中有效性有限.
需要进一步的研究来增强幼儿BAG配方的虫预防潜力.

关键词:

生物活性玻璃的玻璃.童年早期的皮肤损伤.随机对照试验是随机对照试验.牙膏是一种牙膏.

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