解码空气污染物 - 牛皮轴:一个多层系统毒理学调查
Yantao Xu1, Wenpeng Wang2, Xiao-Rui Qiu3
1Department of Urology, The Second Xiangya Hospital at Central South University, Changsha, Hunan 410011, China; Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Ecotoxicology and environmental safety
|October 31, 2025
概括
空气污染可能会通过破坏免疫路径使牛皮变得更糟. 我们的研究确定了关键基因,并表明多烯可能会影响免疫点,为环境健康策略提供了见解.
科学领域:
- 环境健康 环境健康
- 免疫毒理学 免疫毒理学
- 计算生物学 计算生物学
背景情况:
- 流行病学数据将空气污染与像牛皮这样的免疫媒介疾病联系起来.
- 连接空气污染和牛皮的分子机制在很大程度上是未知的.
- 传统毒理学专注于单一的毒剂限制了对复杂的环境暴露的理解.
研究的目的:
- 研究空气污染物可能影响牛皮的免疫毒性机制.
- 为了确定潜在的免疫标和生物标志物,与沙发病中的空气污染暴露相关.
- 开发一个计算框架来分析环境暴露和免疫介导疾病.
主要方法:
- 从公共数据库中编译了与牛皮相关的和与污染物相关的基因.
- 进行了网络毒理学分析 (蛋白质与蛋白质相互作用,途径丰富).
- 开发机器学习分类器以识别诊断基因签名,并进行分子对接模拟.
主要成果:
- 确定了51个重叠的基因,富含IL-17,JAK-STAT和细胞因子信号通路.
- 在验证数据集中,12个基因签名显示出高诊断性能 (AUC 0.911-0.966).
- 分子对接揭示了多烯对免疫点AHR,JAK1和NOS2.2的高结合亲和力.
结论:
- 结合网络毒理学和机器学习的综合性框架阐明了空气污染对牛皮的免疫毒性影响.
- 确定了与空气污染相关的免疫干扰的候选生物标志物.
- 研究结果支持针对性环境健康干预措施,以预防和治疗牛皮.
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