系统性免疫炎症指数和流产之间的关联:一个病例对照研究.
KeXin Sun1, DeHua Zhou2, XiaoLei Xie2
1Department of Pediatric, Ruian City People's Hospital, Wenzhou, Zhejiang Province, China; Department of Gastroenterology, Cicheng Town Central Health Center, Ningbo, Zhejiang Province, China.
Journal of reproductive immunology
|October 31, 2025
概括
较高的第一季度系统性免疫炎症指数 (SII) 水平与更高的流产风险有关. 这种炎症生物标志物可能有助于预测早期妊娠流产,特别是在考虑体重指数时.
科学领域:
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 系统性免疫炎症指数 (SII) 是一个新兴的炎症生物标志物.
- 以前关于SII在预测怀孕结果中的作用的研究是不一致的.
- SII与流产风险之间的关联需要进一步澄清.
研究的目的:
- 调查第一季度SII水平与流产风险之间的关联.
- 评估SII作为早期妊娠损失的潜在预测生物标志物.
主要方法:
- 追溯研究包括2022年1月至12月的785例怀孕.
- 多变量逻辑回归分析以评估SII-流产关系.
- 相互作用分析以探索BMI,年龄和病史等共变量的影响.
主要成果:
- 在第一季度SII升高和流产风险增加之间发现了显著的关联.
- 每增加100个单位的SII与更高的流产几率相关.
- 高SII水平 (≥1296.2) 增加了流产的风险 (OR:1.75;95%CI:1.12-2.74).
- 观察到SII和体重指数之间的相互作用,表明对流产风险的综合影响.
结论:
- 第一季度SII水平升高与流产风险增加有显著关联.
- SII可以作为流产的有价值的预后指标.
- 需要进一步的研究来探索SII和BMI在怀孕结果中的相互作用.
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