空气污染物与一般人群中的动脉硬之间的关联:系统性审查和元分析
María José Rodríguez-Sánchez1, Alicia Saz-Lara2, Iván Cavero-Redondo2
1CarVasCare Research Group, Faculty of Nursing, University of Castilla la Mancha, Cuenca, Spain; Hospital Virgen de la Luz, Cuenca, Spain.
Public health
|October 31, 2025
概括
对臭氧 (O3),颗粒物 (PM10,PM2.5) 和二氧化硫 (SO2) 的暴露会增加成人动脉硬度. 这一系统性审查强调了与常见空气污染物相关的心血管风险.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 流行病学 流行病学
背景情况:
- 动脉硬是心血管疾病的重要预测因素.
- 暴露于环境空气污染是一个日益严重的公共卫生问题.
- 了解空气污染物和动脉硬之间的联系对于预防策略至关重要.
研究的目的:
- 系统地审查和元分析暴露于特定空气污染物和一般人群中的动脉硬之间的关联.
- 量化与O3,PM10,PM2.5和SO2等污染物相关的动脉硬的风险.
主要方法:
- 在PubMed,Web of Science,Cochrane图书馆和Scopus数据库中进行了全面的搜索.
- 通过DerSimonian和Laird方法进行了系统审查和元分析.
- 针对空气污染物 (CO,NO2,O3,PM10,PM2.5,SO2) 和动脉硬之间的关联,计算了聚合风险比率 (RR) 和95%置信区间 (CI).
主要成果:
- 这项分析包括了13项观察性研究,涉及257,784名成年人.
- 在动脉硬度和O3 (RR:1.13,95%CI:1.01-1.26) PM10 (RR:1.23,95%CI:1.03-1.48) PM2.5 (RR:1.23,95%CI:1.04-1.45) 和SO2 (RR:1.25,95%CI:1.06-1.49) 之间发现了显著的关联.
- 对于一氧化碳 (CO) 或二氧化 (NO2) 没有发现显著的关联.
结论:
- 对O3,PM10,PM2.5和SO2的暴露与一般人群的动脉硬度增加有关.
- 这些发现强调了特定空气污染物的有害心血管影响.
- 需要进一步的研究来阐明这种关联的机制和长期影响.
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