建皮吉颗粒通过AMPK/PGC-1α轴在SAMP8小鼠中改善与衰老相关的肉症
Zhe Pan1, Yujie Zhang1, Jiali Zhang1
1Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
概括
皮吉颗粒 (JQG) 通过增强肌肉质量和功能,有效地对抗与年龄相关的肉症. 这种传统中医药激活AMPK/PGC-1α通路,为肉症提供了有前途的治疗方法.
科学领域:
- 老年学和肌肉生理学
- 传统中国医学的机制
- 衰老的分子生物学
背景情况:
- 肉,肌肉质量和功能与年龄相关的下降,导致不良健康结果和显著的医疗保健费用.
- 目前缺乏对萨尔科佩尼亚的药理疗法.
- 传统中医药中的 Jianpi Qiangji 颗粒 (JQG) 显示出潜力,但其机制尚不清楚.
研究的目的:
- 调查JQG对与年龄相关的肉症的治疗效果.
- 阐明JQG在肉症中的作用的潜在分子机制.
主要方法:
- 在体内研究中,使用了sarcopenic小鼠模型来评估JQG对身体组成,肌肉组织学和衰老表型的影响.
- 用JQG处理的细胞和途径抑制剂进行体外实验以确认机制.
- 转录基因分析 (RNA测序) 和西方抹杀以确定关键的分子途径.
主要成果:
- JQG治疗显著改善了瘦身质量,运动能力和肌肉纤维大小,同时减少了脂肪质量和肌肉缩.
- JQG减弱了肌肉衰老标志物,并逆转了与年龄有关的纤维类型变化.
- JQG激活了AMP激活蛋白激酶 (AMPK) /氧酶增殖器激活受体 γ 协同激活器-1α (PGC-1α) 信号通路,这对其抗缩作用至关重要.
结论:
- 通过增强肌肉质量,功能和减少衰老,JQG有效地改善了与年龄相关的肉症.
- AMPK/PGC-1α轴是JQG在肉症中的治疗效益的关键调解器.
- JQG为预防和治疗肉症提供了一个有前途的治疗候选者.
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