转录因子NFIL3驱动了从淋巴细胞原始细胞的先天性淋巴细胞特异性
Joseph Léger1, Eva Artano1, Delphine Coulais1
1Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, 44007 Nantes, France.
Immunity
|October 31, 2025
概括
核因子,干白素3调节 (NFIL3) 对于启动先天性淋巴细胞 (ILC) 发育至关重要. 这项研究揭示了NFIL3.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 天生的淋巴细胞 (ILCs) 对免疫和组织平衡至关重要.
- 了解ILC规范机制是了解其功能的关键.
- 对于ILCs的早期发育途径仍然不完全理解.
研究的目的:
- 阐明先天性淋巴细胞 (ILC) 规范的启动机制.
- 确定涉及早期ILC发展的关键转录因子.
- 开发一种用于产生ILC血统细胞的体外方法.
主要方法:
- 使用Il7r血统追踪小鼠模型来识别ILC发育中间体.
- 对已识别的发育中间体进行了转录分析.
- 通过敲击和强制表达研究在体外和体内实验室和体内实验室研究核因子,受调节的介质蛋白3 (NFIL3) 的作用.
主要成果:
- 在小鼠骨髓中鉴定出具有早期核因子,干白素3调节 (NFIL3) 表达的发育中间体.
- Nfil3淘汰赛小鼠缺乏所有骨髓ILC指定的前体.
- 强制性NFIL3表达在淋巴细胞原始体中产生了所有ILC子集和自然杀手细胞,复述了体外ILC的发展.
结论:
- 核因子,干白素3调节 (NFIL3) 在启动先天性淋巴细胞 (ILC) 规范方面发挥着关键作用.
- NFIL3诱导关键的转录调节器 (Tox, Id2, Gata3, Tcf7, Zbtb16),这些调节器对于ILC的发展至关重要.
- 这项研究为产生具有治疗潜力的ILC血统细胞提供了一种新的体外方法.
相关概念视频
NF-κB-dependent Signaling Pathway
9.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
9.8K
Lineage Commitment
4.1K
Commitment is the process whereby stem cells:
4.1K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.4K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.4K
Cells of the Adaptive Immune Response
8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K
Master Transcription Regulators
7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K
Mechanism of Filopodia Formation
3.0K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
3.0K


