相关实验视频

Updated: Apr 19, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

用机械血栓切除术治疗的缺血性中风中的预后生物标志物:系统性审查

Rodrigo Fellipe Rodrigues^1,2, Raquel Cristina Trovo Hidalgo³, Savio Batista⁴

¹Universidade Federal de São Paulo, Programa de Pós-Graduação em Biologia Estrutural e Funcional, São Paulo, SP, Brazil.

Arquivos de neuro-psiquiatria

|October 31, 2025

概括

像CRP和NLR这样的生物标志物预测了急性缺血性中风 (AIS) 机械血栓切除术 (MT) 的结果. 这些标志物有助于识别患有并发症和MT后恢复不良风险较高的患者.

科学领域:

神经学神经学
生物化学生物化学
医学诊断医学诊断医学诊断

背景情况:

机械血栓切除术 (MT) 对急性缺血性中风 (AIS) 至关重要,但结果各不相同.
需要预测标记来优化对MT的患者选择.
炎症和代谢应激生物标志物越来越多地被认为在AIS和MT中的作用.

研究的目的:

系统地审查和综合有关AIS患者接受MT的临床结果的生物标志物的证据.
评估生物标志物与功能恢复 (mRS),死亡率,心脏病发作量以及诸如出血转变和恶性脑 (MBE) 等并发症的关系.

主要方法:

按照PRISMA指南进行系统的文献审查.
在PubMed和Embase数据库中搜索了关于中风中的生物标志物和MT的研究.
包括来自2834篇识别文章的86项研究.

主要成果:

一些生物标志物,包括C-反应蛋白 (CRP),中性粒细胞与淋巴细胞比率 (NLR),腺氨酸脱胺酶 (ADA),神经元特异性乙醇酶 (NSE) 和矩阵金属蛋白酶-9 (MMP-9),与更糟糕的结果有关.
这些生物标志物与功能恢复较差,死亡率增加以及出血转变和MBE的风险更高相关.
多种生物标志物在接受MT治疗的AIS患者中显示出预后价值.

结论:

生物标志物可以预测接受MT的AIS患者的临床结果.
这些发现支持风险分层和个性化治疗方法.
需要进一步的前性研究来将这些生物标志物纳入临床实践.

更多相关视频

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

相关概念视频

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...