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循环mRNA作为头癌的炎症生物标志物

Liu Yanxi¹, Rabiatul Basria S M N Mydin¹, Muhamad Yusri Musa²

¹Department of Biomedical Science, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia.

Clinica chimica acta; international journal of clinical chemistry

|October 31, 2025

概括

在头癌 (HNC) 中,循环信使RNA (mRNA) 反映了免疫变化和炎症. 这些生物标志物可以预测治疗耐药性和复发,提供诊断和治疗潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

循环信使RNAs (mRNAs) 是头癌 (HNC) 的新兴生物标志物.
这些分子为瘤微环境的炎症和全身免疫反应提供了洞察力.
了解这些mRNA可以将瘤生物学与临床结果联系起来.

研究的目的:

探索与炎症相关的循环mRNA在头癌中的作用.
研究它们作为疾病进展和治疗反应的生物标志物的潜力.

主要方法:

分析循环的mRNA概况,可能在外体或亡体内.
特定的mRNA转录 (例如IL6,IL10,TNFα,HMOX1) 与瘤特征和临床结果的相关性.

主要成果:

循环的mRNA反映了瘤微环境 (TME) 中的炎症事件.
特定的转录与血管生成,免疫逃避和治疗反应不佳有关.
这些mRNA显示出作为复发和治疗耐药性的预测因子的潜力.

结论:

循环的mRNA反映了系统性免疫动态,并有助于HNC的进展和治疗耐药性.
与炎症相关的循环mRNA在HNC中具有诊断和治疗潜力.
将mRNA概况与多omics整合起来,可能会促进HNC的精确瘤学.

关键词:

生物标志物生物标志物癌症癌症癌症癌症在循环中的mRNA.疾病疾病疾病头部和部癌症头部和部癌症炎症生物标志物炎症生物标志物

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...