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Updated: Jan 12, 2026

Isolation and Ex Vivo Culture of Vδ1+CD4+γδ T Cells, an Extrathymic αβT-cell Progenitor
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Published on: December 7, 2015

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发育性血液形成:αβ T 细胞的先天编程

Isabel M Forlastro1, Norah L Smith1, Emily N Kulp1

  • 1Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY.

Experimental hematology
|October 31, 2025
PubMed
概括

免疫系统从与生相似的淋巴细胞发展为适应性淋巴细胞. 这篇综述强调了造血源,而不仅仅是胸膜选择,影响了α-βT细胞的发育,挑战了现有的观点.

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Lineage Commitment

Commitment is the  process whereby stem cells:
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