检查神经精神症状和功能下降的行为变体前性痴呆症
Christopher B Morrow1, Eric Sah1,2, Chiadi U Onyike1
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
概括
神经精神症状 (NPS) 在行为变异前性痴呆症 (bvFTD) 中很常见,并且与功能衰退有关. 早期识别和管理NPS可以帮助保持bvFTD患者的功能.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 是行为变异前性痴呆症 (bvFTD) 的核心.
- 在bvFTD中NPS和功能衰退之间的关系尚未完全理解.
研究的目的:
- 调查NPS与早期bvFTD功能衰退之间的关联.
- 描述NPS在bvFTD中的患病率和对日常功能的影响.
主要方法:
- 分析了219名患有早期bvFTD的参与者.
- 功能状态使用功能活动问卷进行评估.
- 通过神经精神病学清单问卷和临床医生的判断收集了NPS数据;使用了Cox比例危险分析.
主要成果:
- 常见的基线NPS包括冷漠 (65%) 和无抑制 (55%).
- 在交易 (47%) 和口头沟通 (44%) 中的功能障碍在基线时很常见.
- 新兴的冷漠,无抑制,抑郁,焦虑和易怒与行走,准备饭菜,自我照顾和交易功能下降的风险增加相关.
结论:
- NPS是普遍存在的,并且在bvFTD的早期发生.
- NPS与bvFTD的功能衰退有显著的相关性.
- 早期发现和干预NPS可能有助于减轻bvFTD的功能障碍.
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