流感疫苗接种在热带环境中的实际有效性和随后的减弱:一个回顾性队列研究

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Updated: Jan 12, 2026

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Liang En Wee¹, Reen Wan Li Ho², Jue Tao Lim³

¹Communicable Diseases Agency, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|October 31, 2025

概括

在热带地区,流感疫苗的有效率为37%,在六个月后显著下降. 然而,接收三剂或更多剂量的个体没有显著减弱,这表明增加再接种频率可能会改善保护.

科学领域:

热带医学是一种热带医学.
疫苗学疫苗学疫苗学
流行病学流行病学

背景情况:

关于在热带地区全年传播的流感疫苗有效性的数据有限.
在COVID-19复发后评估疫苗的有效性对于公共卫生战略至关重要.

研究的目的:

为了评估真实世界的流感疫苗在热带环境中的有效性.
评估重复接种疫苗对疫苗有效性和衰减的影响.

主要方法:

成年新加坡人的基于人口的回顾性队列研究 (2022年5月至2024年4月).
考克斯回归与重叠权重分析流感住院风险.
后勤回归用于评估先前接种疫苗剂量的减弱和影响.

主要成果:

在老年人 (≥65岁) 中,抗流感住院的总体疫苗有效率为37%.
在接种疫苗18-25周后,有效性下降到基线的43%.
在过去两年中,≥3个疫苗剂量没有显著减弱.

结论:

在热带地区,流感疫苗的有效性是中等的 (37%),并且随着时间的推移而减弱.
增加再接种频率,特别是两年内≥3剂,可能会减轻衰退.
这些发现支持在热带地区以持续流行的流感疫苗接种策略.

关键词:

免疫力受损的人.流感是一次流感.这是一个热带热带.疫苗接种疫苗接种疫苗的有效性疫苗的有效性逐渐衰落的衰落的

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