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从HypoG-01第三阶段试验中的个别DICOM数据进行全面的放射治疗质量保证分析

Thomas Brion¹, Mamadou Balde², Rodrigue Allodji²

¹Radiation Oncology, Institut Curie, Paris, France.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|October 31, 2025

概括

在放射治疗 (RT) 试验中,质量保证 (QA) 是必不可少的. 在HypoG-01试验试验.

科学领域:

辐射瘤学辐射瘤学
临床试验临床试验
质量保证质量保证质量保证

背景情况:

质量保证 (QA) 对放射治疗 (RT) 临床试验的完整性至关重要.
在HypoG-01III期试验中,研究了乳腺癌患者的不同RT疗法.

研究的目的:

在HypoG-01第三阶段试验中对个体放射治疗计划进行前性质量保证 (QA) 分析.
评估协议合规性,并识别参与中心RT规划中的差异.

主要方法:

在HypoG-01试验中,从1,093名乳腺癌患者中收集和分析RT计划.
对体积定义,剂量测量约束和危险器官划分的协议合规性的评估.
在RT规划中对中心内和中心间变化的描述性分析.

主要成果:

对处方剂量 (99.2%) 和危险器官划分 (95.2%-100%) 的高度遵守.
变量符合规划目标量 (CTV) 约束,范围从42.9%到90.4%.
符合风险器官 (OAR) 约束的高率 (63.4%-93.7%),有显著的中心内和中心间变异性.

结论:

轮和RT规划的异质性需要在临床试验中严格的质量保证.
质量保证分析表明,治疗臂之间的结果可比,支持HypoG-01试验结果的稳定性.
该研究为未来的RT试验QA提供了一个可扩展的框架.

关键词:

乳腺癌乳腺癌乳腺癌低分化是一种低分化.地方区域辐射疗法.质量保证质量保证质量保证瘤床的增强促进

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