辅助生殖技术和食道缩:危险的联系?
C Iacusso1, L Valfré1, B D Iacobelli1
1Neonatal Surgery Unit, Area of Fetal, Neonatal and Cardiological Sciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Journal of pediatric surgery
|October 31, 2025
概括
辅助生殖技术 (ART) 与新生儿食道缩 (EA) 的可能性更高有关. 然而,ART似乎没有影响EA的整体严重程度.
科学领域:
- 医学研究 医学研究
- 生殖健康 生殖健康
- 儿科外科手术 儿科外科手术
背景情况:
- 辅助生殖技术 (ART) 在全球越来越普遍.
- 人们越来越担心ART和先天性异常之间的潜在联系.
- 食道 (EA) 是一种先天性异常,食道不能正确形成.
研究的目的:
- 调查食道 (EA) 和辅助生殖技术 (ART) 之间的关联.
- 确定ART是否影响EA的复杂性.
- 通过ART怀孕的EA患者与自发怀孕的患者进行比较.
主要方法:
- 追溯病例控制研究设计.
- 包括203名EA患者 (病例) 和203名对照 (无先天性异常的支气管炎患者) 从2013-2023.
- 对ART患病率,妊娠年龄,出生体重和母亲年龄的分析.
主要成果:
- 与对照组 (2,9%) 相比,EA患者 (12.3%) 观察到ART暴露的患病率显著更高.
- 与ART相比,EA的赔率比为4.0 (95%CI:1.7-9.6;p=0.0007).与ART相比,EA的赔率比为4.0 (95%CI:1.7-9.6;p=0.0007).与ART相比,EA的赔率比为4.0 (95%CI:1.7-9.6;p=0.0007).
- 在ART受孕和自发受孕的EA患者之间,在整体EA疾病复杂性方面没有发现显著差异,除了ART组中B型EA的发病率更高.
结论:
- 患有食道缩症 (EA) 的患者通过辅助生殖技术 (ART) 怀孕的可能性更高.
- ART似乎不会影响EA的一般复杂性.
- 可能需要进一步的研究来了解ART和EA亚型之间的特定关系.
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