碎片化QRS与左心室扩张性功能障碍之间的关联在2型糖尿病患者中,有或没有微专尿
Lili Wang1, Linjun Zheng1, Jiayu Hu2
1ECG Department, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 321000, China.
Endocrinologia, diabetes y nutricion
|October 31, 2025
概括
碎片化QRS (fQRS) 和微albuminuria (MAU) 是左心室扩张性功能障碍 (LVDD) 在2型糖尿病 (T2DM) 的独立风险因素. 在没有MAU的患者中,fQRS和LVDD之间的关联更为强烈.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 生物标志物研究 生物标志物研究
背景情况:
- 心血管疾病 (CVD) 是2型糖尿病 (T2DM) 患者的主要死亡原因.
- 左心室扩张功能障碍 (LVDD) 是T2DM心肌功能损失的早期指标.
- 碎片化QRS (fQRS) 和微albuminuria (MAU) 在T2DM中的LVDD发展中的作用需要进一步研究.
研究的目的:
- 调查fQRS和MAU对T2DM患者LVDD的独立影响.
- 分析不同MAU状态如何影响fQRS和LVDD之间的关系.
- 评估fQRS和MAU在T2DM中对心血管风险分层的联合实用性.
主要方法:
- 对374名T2DM患者进行了心电图 (ECG) 和心声图.
- 使用后勤回归分析来确定fQRS,MAU和LVDD之间的关联.
- 分层分析检查了不同MAU级别的fQRS-LVDD关系.
主要成果:
- fQRS,MAU和年龄被确定为T2DM中LVDD的独立风险因素.
- 患有fQRS的患者患LVDD的风险增加了3.72倍;患有MAU的患者患LVDD的风险增加了4.05倍.
- 在没有MAU的患者中,fQRS-LVDD相关性是显著的 (OR=7.084),但在MAU患者中没有 (OR=1.499).
结论:
- fQRS和MAU是T2DM中LVDD的重要独立风险因素.
- 存在MAU会降低fQRS对LVDD的预测值.
- 对fQRS和MAU的综合评估可以提高心血管风险评估,并指导T2DM个性化干预.
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