遗传和条形状结构联系将行为抑制/激活系统与青少年焦虑和抑郁联系起来
Jing Lou1, Xiaohan Tian1, Yuqing Sun1
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Translational psychiatry
|November 1, 2025
概括
对行为抑制系统 (BIS) 和行为激活系统 (BAS) 的遗传倾向影响青少年的大脑结构和情绪脆弱性. BIS风险与焦虑有关,而BAS风险与抑郁有关,揭示了不同的基因-大脑通路.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 对于情绪调节至关重要的行为抑制和激活系统 (BIS/BAS) 的遗传和神经基础尚未完全理解.
- 青春期是情感障碍出现的关键发育时期,突出了在这段时间内调查情感脆弱性的遗传和神经机制的需要.
研究的目的:
- 调查青少年BIS/BAS多基因风险与条形状结构连接性之间的关系.
- 探索这些遗传因素如何与不同的情绪脆弱性有关,特别是焦虑和抑郁.
主要方法:
- 利用了来自ABCD研究的1,929名青少年的数据.
- 使用全基因组关联研究 (GWAS) 数据计算了BIS和BAS的多基因风险得分 (PRS).
- 采用连带图绘制和奇点值分解 (SVD) 来分析条状结构梯度 (SSG) 以及它与PRS的相关性.
主要成果:
- 对BIS和BAS的多基因风险显示出对条纹结构梯度 (SSG) 的可分离影响.
- 增加的BIS PRS与增加的焦虑症状有关.
- 增加的BAS PRS与抑郁和退缩特征有关.
结论:
- 研究结果阐明了一种神经解剖学形机制,在这种机制中,共享的条纹连接路径将遗传易感性差异性地引导到不同的情绪症状维度中.
- 这有助于我们更好地理解导致情绪脆弱和青少年精神病现象的神经通路.
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