免疫调节疫苗证明了跨癌症类型的治疗疗效
Tiyun Han1, Guilai Liu1, Chenyi Bao2,3
1Nanjing Chengshi (TheraRNA) Biomedical Technology Co. Ltd., Nanjing, 210000, China.
Scientific reports
|November 1, 2025
概括
一种新的mRNA-脂质纳米粒子 (LNP) 疫苗有效地重新编程瘤微环境 (TME),以增强抗瘤免疫力. 这种癌症疫苗表现出良好的耐受性,并在75%的治疗犬中实现了稳定的疾病,跨越各种恶性瘤.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗开发 疫苗开发
背景情况:
- 瘤微环境 (TME) 免疫抑制阻碍了抗瘤免疫力,这对癌症治疗提出了挑战.
- 目前的多目标免疫调节策略是有限的.
研究的目的:
- 开发和评估一种新的mRNA-脂质纳米粒子 (LNP) 疫苗,该疫苗旨在重编程TME内的免疫抑制的关键介质.
- 评估疫苗在患有自发性瘤的狗中有效性和安全性.
主要方法:
- 开发了一种mRNA-LNP疫苗,该疫苗向C-C基因化学因体22 (CCL22),转化生长因子β (TGF-β),细胞毒性T-淋巴细胞相关蛋白4 (CTLA-4),加列-3,编程细胞死亡因体1 (PD-L1),地胺2,3-二氧化酶1 (IDO1),地酶1 (ARG1).
- 给一群自发上腺,肝脏,周,阴道和肺部恶性瘤的狗进行了疫苗接种.
- 监测不良事件,疾病进展和血液/生化异常.
主要成果:
- 该疫苗在25%的受试者中表现出良好的耐受性与轻度不良事件.
- 75%的接受治疗的动物 (6/8) 获得了稳定的疾病,疾病控制率为75%.
- 接种疫苗逆转了血液/生化异常,并缓解了副瘤综合征.
结论:
- mRNA-LNP疫苗在犬类的各种癌症类型中显示出显著的抗瘤作用.
- 这种新型疫苗代表了增强兽医和人类瘤学中抗瘤免疫力的有希望的策略.
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