硫化对指甲病原体的抗菌作用和机制
Fritz Ka-Ho Ho1, Alyaa Al-Tabtabai2, Sara M Nasereddin2,3
1Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Scientific reports
|November 1, 2025
概括
硫化 (H2S) 对抗指甲感染病原体具有强大的抗菌活性. 局部输送H2S捐赠者提供了一个有前途的新治疗因其入指甲和新的机制.
科学领域:
- 生物化学 生物化学
- 微生物学 微生物学
- 皮肤病学 皮肤病学
背景情况:
- 爪子感染,比如甲状腺炎,很难治疗.
- 目前的口服和局部治疗有局限性,包括不良影响和不良的指甲透.
- 硫化 (H2S) 是一个极性小分子,具有已证明的抗微生物特性和出色的指甲穿透能力.
研究的目的:
- 调查硫化 (H2S) 对指甲感染病原体的疗效.
- 阐明H2S在对抗这些感染的作用机制.
- 探索局部H2S输送作为一种新肌病治疗的潜力.
主要方法:
- 使用硫化 (NaHS) 作为H2S供体.
- 测试了对指甲感染的真菌和细菌病原体的H2S活性.
- 进行了转录基因分析,以了解细胞反应.
- 研究了细胞染色体C氧化酶 (COX) 和活性氧物种 (ROS) 生成的抑制.
主要成果:
- H2S对导致指甲感染的关键病原体表现出强大的抗菌活性.
- 与HS−相比,H2S的活性形式可能是H2S,这是由于细胞吸收的速度较快.
- H2S抑制了COX,增加了ROS,并诱导了蛋白质S-硫化,表明一种新的抗菌机制.
- 转录组分析揭示了与细胞应激反应相关的显著基因表达变化.
结论:
- 局部应用H2S捐赠体是一种有前途的策略,用于治疗桃菌.
- 涉及COX抑制,ROS生成和S-硫的新型机制有助于H2S的抗菌作用.
- 由于H2S能够穿透指甲板,因此提高了它对指甲感染的治疗潜力.
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