在出生后的前六个月中,大脑网络的空间发展
Masoud Seraji1,2, Sarah Shultz3,4, Qiang Li5
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. m.seraji@utexas.edu.
Communications biology
|November 1, 2025
概括
婴儿大脑网络在出生至6个月期间显著成熟,显示出空间相似性和强度的增加. 这种发育巩固在生命早期完善了功能性大脑组织.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 产后早期对于大脑发育至关重要.
- 了解神经发育障碍需要了解大脑早期的成熟.
- 婴儿时期大脑网络的空间发展尚未得到充分探索.
研究的目的:
- 描述从出生到6个月的婴儿大脑网络的空间演变.
- 识别功能性大脑网络的空间组织中的与年龄相关的变化.
- 建立一个评估典型和非典型早期大脑发育的框架.
主要方法:
- 纵向静止状态功能磁共振成像 (rs-fMRI) 数据来自74名神经类型婴儿.
- 独立组件分析 (ICA) 用于分析空间网络特征.
- 网络平均空间相似性,接触范围,强度,尺寸和质量中心的量化.
主要成果:
- 观察到与年龄相关的网络平均空间相似性的显著增加.
- 网络参与范围随着年龄的增长而下降,这表明了整合过程.
- 网络强度在前端-中端前额叶皮质和视觉网络中增加.
- 时间网络显示了尺寸的增加和质量中心的改变.
结论:
- 婴儿早期的大脑发育涉及功能网络的显著空间重组.
- 网络拓,大小和相似性的可量化的变化为大脑成熟提供了洞察力.
- 这项研究为识别婴儿非典型神经发育轨迹提供了基础.
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