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Updated: Jan 12, 2026

Self-Assembly of Microtubule Tactoids
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通过BAG3和HSP70引导的与actin结合蛋白的共同聚合,形成了TDP-43骨状的内含物

Shan Lu1,2, Sitao Zhang3, Spencer Oung3

  • 1Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA, USA. ms.shanlu@gmail.com.

Nature cell biology
|November 1, 2025
PubMed
概括

RNA结合蛋白TDP-43在神经退行性疾病中形成不同的聚合物. 它的自我氧化和与菲拉胺和BAG3等蛋白质的相互作用影响聚合物的类型和毒性.

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