在尼罗河鱼 (Oreochromis niloticus) 中, cefuroxime 的药理动力学和生物利用性
Orhan Corum1, Duygu Durna Corum2, Pedro Marin3
1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, 31060, Türkiye. orhancorum46@hotmail.com.
Veterinary research communications
|November 1, 2025
概括
塞福洛キシ姆的药理动力学在尼罗河鱼中进行了评估. 腹腔内和肌肉内注射显示出高生物可用性,表明对鱼类感染的疗效,而口服需要改进配方.
科学领域:
- 水生动物的健康状况.
- 药理学 药理学是指药理学的学科.
- 兽医医学 兽医医学 兽医医学
背景情况:
- 素是一种广泛的抗生素,用于人类和动物医学.
- 虽然它对某些鱼类感染有效,但其在水生物种中的药理动力学尚未得到充分记录.
- 了解素在鱼类中的行为对于有效治疗水产养殖中的疾病至关重要.
研究的目的:
- 在尼罗河鱼 (Oreochromis niloticus) 中评估 cefuroxime 的药理动力学.
- 为了比较 cefuroxime 在静脉内,腹腔内,肌内和口服后的药物动力学概况.
- 根据药理动力学数据来确定适当的剂量间隔以获得治疗疗效.
主要方法:
- 288只尼罗河鱼通过四种途径 (IV,IP,IM和口服) 服用了素 (20毫克/公斤).
- 在96个小时内从每个治疗组的鱼群中采集了血液样本.
- 使用高性能液体染色学量化血 cefuroxime 度,并通过非分区分析进行分析.
主要成果:
- 静脉注射的半衰期 (t1/2yz) 为8.04小时,分布体积 (Vdss) 为1.03L/kg,清除量 (ClT) 为0.14L/h/kg.
- 血中度 (Cmax) 的峰值为53.38微克/毫升 (IP),28.70微克/毫升 (IM),6.77微克/毫升 (口服).
- 在IP (80.26%) 和IM (69.05%) 路径中,生物利用率很高,但在口服中 (24.35%) 显著下降.
结论:
- 肠内和肌肉内注射的 cefuroxime 适用于小,建议的剂量间隔为 24 小时,MIC ≤ 1 μg/mL.
- 在鱼中,口服素的生物可用性很低,因此需要进一步研究改善水产养殖的配方.
- 未来的研究应该专注于开发增强的口服输送系统,证明感染鱼的治疗成功,并评估组织残留物耗尽.
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