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相关概念视频

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.4K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.4K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.2K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.4K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

17.1K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
17.1K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.8K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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相关实验视频

Updated: Jan 12, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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类似神经化的蛋白质差异地激活了诺奇连接体.

Alina Airich1, Oren Gozlan2, Ekaterina Seib1

  • 1Institut fuer Genetik, Heinrich-Heine-Universtitaet Duesseldorf, Universitaetstr. 1, 40225, Duesseldorf, Germany.

EMBO reports
|November 1, 2025
PubMed
概括
此摘要是机器生成的。

神经化样蛋白 (NEURL) 调节哺乳动物的Notch信号传递方式与的不同. NEURL蛋白只激活含有神经化结合基因的特定Notch配体 (DLL1和JAG1),这解释了它们在发育中的有限作用.

关键词:
在DSL连接体中,连接体的连接体是:E3 无处不在酸酶.神经化的神经系统.没有口的信号.

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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相关实验视频

Last Updated: Jan 12, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

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8.3K
Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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科学领域:

  • 细胞生物学 细胞生物学
  • 发育生物学是发展生物学.
  • 分子信号传递是分子信号传递.

背景情况:

  • 痕信号协调动物细胞过程.
  • 神经化 (神经) 和Mindbomb1 (Mib1) E3 泛素连接酶调节了Drosophila中的Notch.
  • 哺乳动物NEURL蛋白似乎对发育是不可或缺的,这引发了关于它们的功能的问题.

研究的目的:

  • 研究NEURL蛋白质如何调节哺乳动物的Notch配体.
  • 确定NEURL蛋白是否表现出差异性联体激活.
  • 澄清NEURL蛋白在哺乳动物发育和恒温的作用.

主要方法:

  • 利用一个人性化的Drosophila模型来研究NEURL蛋白质功能.
  • 使用哺乳动物细胞培养系统进行分析.
  • 通过NEURL蛋白质检查了诺奇配体的激活,并确定了一个特定的结合动机.

主要成果:

  • 与MIB1.1不同的是,NEURL蛋白激活了哺乳动物诺奇配体的一个子集.
  • 通过NEURL激活配体取决于神经化结合基因 (NxxN) 的存在.
  • DLL1 和 JAG1 带含有这种基因,而 DLL4 和 JAG2 则没有.

结论:

  • 哺乳动物的Notch激活表现出NEURL蛋白质的差异调节.
  • 神经化结合基因的存在决定了NEURL介导的配体激活.
  • 这种差异性机制可能解释了NEURL蛋白在哺乳动物发育中的有限的体内作用.