针对老年人的新型配方食品调节了特定的肠道细菌种群,并改善了宿主生理
Yue Xiao1, Yangqian Xiao2, Xinyi Wang2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China.
Food research international (Ottawa, Ont.)
|November 1, 2025
概括
富含益生菌的新型老年人配方食品 (NFFE) 通过调节肠道微生物群和增加有益细菌,改善了与衰老相关的生理衰退. 个性化的反应凸显了定制饮食干预措施的必要性.
科学领域:
- 老年学是指老年学的学科.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道微生物群和宿主衰老是相关的,有潜在的饮食干预措施来缓解与年龄相关的衰退.
- 现有的针对老年人的营养配方往往缺乏全面和平衡的营养特征.
- 益生菌因其在调节肠道微生物群组成和功能方面的作用而得到认可.
研究的目的:
- 开发和评估针对肠道微生物群和营养需求的针对老年人新型配方食品 (NFFE).
- 评估NFFE对与年龄相关的生理衰退和肠道微生物群组成的影响.
- 调查宿主微生物群相互作用,并确定影响个人对干预反应的因素.
主要方法:
- 一个为期8周的随机自我控制试验,涉及老年参与者.
- 富含益生菌的NFFE配方 (果物糖和真菌β-葡萄糖).
- 对肠道微生物群组成,短链脂肪酸 (SCFA) 生产细菌和宿主生理参数的分析.
- 相互作用网络分析以阐明微生物代谢途径和宿主响应物分层.
主要成果:
- NFFE干预显著缓解了与年龄相关的生理衰退.
- 选择性丰富SCFA产生细菌,包括Bifidobacterium (+42%) 和Ruminococcus (+35%).
- 根据基线微生物群和对NFFE的反应,识别出不同的高响应群和低响应群,高响应群显示出更大的改善.
结论:
- 通过肠道微生物群调节和营养支持,NFFE是一种有前途的饮食干预措施,用于打击与年龄相关的衰退.
- 这项研究强调了肠道微生物群中的代谢中继,用于益生菌降解.
- 基线微生物群组成会影响个体反应,强调个性化营养策略的潜力.
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