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对原牛奶生物膜中Enterococcus lactis FSEL1的过氧化介导的抗菌活性进行转录基因洞察

Ga-Hee Ban¹, Jae-Ik Lee², Dong-Hyun Kang³

¹Department of Food Science and Biotechnology, Ewha Womans University, Seoul 03760, Republic of Korea.

Food research international (Ottawa, Ont.)

|November 1, 2025

概括

生牛奶中的Enterococcus lactis FSEL1表现出强大的抗菌活性,对抗常见的食源性病原体,如金黄色葡萄球菌和单细胞菌菌. 这种天然剂通过其杀菌性质显示出增强食品安全和保存的希望.

科学领域:

食品微生物学食品微生物学
细菌学细菌学是一门学科.
基因组学就是基因组学.

背景情况:

生牛奶含有大量的致病细菌,对食品安全构成风险.
寻求天然抗菌剂用于食品保存和病原体控制.
乳腺肠球菌具有多样化的代谢能力,包括潜在的抗微生物生产.

研究的目的:

评估Enterococcus lactis FSEL1对关键原奶病原体的杀菌潜力.
描述与抗微生物活性相关的E. lactis FSEL1的基因组和转录组特征.
评估E. lactis FSEL1作为天然食品防腐剂的安全性和有效性.

主要方法:

基因组测序和E. lactis的比较基因组分析 FSEL1.1.
共同培养生物膜测试以评估对黄金葡萄球菌,单细胞菌菌和大肠杆菌O157:H7.7的抗菌活性.
转录基因分析和体外测试以确定抗微生物机制,包括细菌的产生和过氧化的活性.

主要成果:

E. lactis FSEL1在共同培养中显示出S. aureus和L. monocytogenes种群的显著减少,特别是在牛奶中.
基因组分析证实了E. lactis FSEL1的特异性,并确定了细菌素 (溶素A,素P) 的基因.
过氧化被确定为对抗大肠杆菌O157:H7的关键因素,在共同培养期间对新型细菌素基因进行上调.

结论:

乳腺肠杆菌 (Enterococcus lactis) FSEL1是一种有前途的天然抗菌剂,有效对抗主要原奶病原体.
该菌株具有较低的毒性潜力,使其成为食品应用的安全候选者.
E. lactis FSEL1为改善食品安全和延长食品的保质期提供了一个可行的策略.

关键词:

具有杀菌作用的细菌.乳腺肠球菌 (Enterococcus lactis) FSEL1 是一个过氧化是一种过氧化.生牛奶生牛奶是什么意思文字转录学 (Transcriptomics) 是一个学科.

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