移动遗传元素可能推动来自猪肉的多药耐药沙门氏菌Derby ST40系的适应性进化:综合分析
Jiawen Chen1, Junhao Peng2, Yanling Liu1
1Laboratory of New Veterinary Drug Development and Safety, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, Shandong, China.
Food research international (Ottawa, Ont.)
|November 1, 2025
概括
耐多药沙门氏菌Derby ST40,通常来自猪肉,造成食品安全风险. 研究追踪了它的演变和全球传播,强调牲畜是抗生素耐药性基因的关键储存库.
科学领域:
- 食物传播的病原体
- 抗微生物耐药性 抗微生物耐药性
- 基因组学就是基因组学.
背景情况:
- 沙门氏菌德比ST40 (S. Derby ST40) 是一种通过受污染的猪肉传播的多药耐药 (MDR) 病原体.
- 它日益流行,在全球范围内带来了重大的食品安全和公共卫生挑战.
- 了解它的演变和传播对于有效控制至关重要.
研究的目的:
- 调查S. Derby ST40中抗生素耐药性的适应性进化和传播动态.
- 确定这种病原体中MDR的遗传基础和地理传播.
- 确定食品生产链在抵抗传播中的作用.
主要方法:
- 综合抗微生物敏感性测试,植物遗传学分析和植物地理重建.
- 利用了全基因组学和全基因组范围的关联研究,对牲畜,食品和环境隔离物进行研究.
- 应用分子时钟分析来确定进化时间线和分歧点.
主要成果:
- 在全球范围内,S. Derby ST40菌株被分为六个分类,其中第六类 (MDR,blaOXA-1阳性) 在中国从第二类演变为第六类.
- 类VI获得了大约19个抗性基因,主要是通过通过移动遗传元素 (MGE) 进行横向基因转移.
- 起源于美国 (1939年),S. Derby ST40 Clade VI在中国 (1979年) 分离,中国成为21世纪的传播枢纽.
结论:
- 畜牧业和食品生产链作为抗生素耐药性基因的储库,猪肉和家禽菌株的耐药性更高.
- 在S. Derby ST40 Clade VI中,MDR的演变是由MGEs和染色体区域驱动的,由重组促进.
- 加强畜牧业的抗生素监管和实施"一个健康"框架对于制耐药性传播和跨境传播至关重要.
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