维生素C在COVID-19管理中的有效性:系统性审查和元分析
Shuyi Zhou1, Shijie Gao1, Yujie Fang1
1School of Public Health, Peking University, Beijing, 100191, China.
BMC infectious diseases
|November 1, 2025
概括
补充维生素C并没有显著改善COVID-19患者的结果. 需要进一步的高质量试验来确认维生素C和COVID-19之间的关联.
科学领域:
- 医学研究 医学研究
- 临床试验 临床试验
- 公共卫生 公共卫生
背景情况:
- COVID-19 提出了一个重大的全球健康挑战.
- 维生素C因其抗氧化和抗炎性质而闻名,被探索为潜在的COVID-19治疗方法.
- 它在管理COVID-19中的临床有效性仍然不确定.
研究的目的:
- 系统地评估维生素C补充剂对COVID-19患者结果的影响.
- 评估维生素C对COVID-19死亡率和其他临床指标的影响.
主要方法:
- 在多个数据库 (PubMed,MEDLINE,Embase等) 中进行了全面的文献搜索. 在2023年10月之前.
- 主要结局包括28天和住院死亡率;次要结局包括ICU停留,机械呼吸,血管压缩剂使用,SOFA得分和PaO2/FiO2比率.
- 随机效应模型和GRADE系统被用于分析数据和评估证据质量.
主要成果:
- 分析了13项涉及12,062名参与者的研究,显示偏差风险低至不确定.
- 证据质量从非常低到中等不等.
- 补充维生素C对短期死亡率 (RR:0.92,P=0.415) 或住院死亡率 (RR:1.05,P=0.286) 或二次结果没有显著的有利影响.
结论:
- 目前的证据表明,维生素C不会显著改善COVID-19的结果.
- 需要进一步进行高质量的多中心临床试验,以澄清维生素C在COVID-19管理中的作用.
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