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在聚甲基甲基酸假牙基上,层层地纳米涂层化含量较高的微粒

Pattarasuda Luanareesatit¹, Norased Nasongkla², Chuchai Anunmana³

¹Residency training program, Department of Prosthodontics, Faculty of Dentistry, Mahidol University, Bangkok, 10400, Thailand.

BMC oral health

|November 1, 2025

概括

这项研究开发了一种新的化 (CHX) 涂层用于假牙基,以对抗Candida albicans. 优化的涂层有效地抑制了真菌生长,并保持了生物相容性,为假牙口腔炎提供了有前途的解决方案.

科学领域:

生物材料科学生物材料科学
口腔微生物学口腔微生物学
表面化学表面化学

背景情况:

假牙口腔炎是一种常见的口腔感染,与假牙基孔隙性和卫生状况不佳有关.
虫 Candida albicans 很容易殖民于假牙表面,导致感染.
开发抗微生物假牙材料对于口腔健康至关重要.

研究的目的:

为了创建氧化 (CHX) 释放表面修改为假牙基.
为了增强抗菌活性对抗白菌.
为了评估CHX涂层假牙基的有效性和生物相容性.

主要方法:

牙膏基被涂层使用一层一层 (LbL) 浸泡涂层工艺,使用CHX载荷的和聚烯酸).
最优化的涂层涉及90层,达到13.33±2.41μm的厚度和23.64±4.71μg/cm2的CHX含量.
评估的涂层厚度,药物含量,CHX释放动力学,抗菌效率和细胞毒性.

主要成果:

经过优化涂层,可以在14天内持续释放CHX.
降低了表面接触角度,并显著抑制了Candida albicans的粘附和生长.
CHX-微粒涂层保持高细胞活力 (>85%),表明与自由的CHX相比具有良好的生物相容性.

结论:

开发的LbL涂层方法有效地创造了抗微生物假牙基.
优化的涂层延长了CHX的释放,抑制了真菌生长,并被证明是生物相容的.
这种方法为预防和管理假牙口腔炎提供了一个有希望的策略.

关键词:

抗微生物药物抗微生物药物赫西丁 (Chlorhexidine) 是一种化学物质.涂层涂层是一种涂层.细胞毒性细胞毒性牙口腔炎是一种牙口腔炎.

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